无创肺功能研究系统

全身体积描记系统（Whole Body Plethysmograph System）用于动物在清醒、无束缚状态下，测量动物的各项肺功能参数。该系统简单、易用、快速、数据输出量大的特点使其成为国外药企研发机构喜爱的研究工具，主要用于哮喘等新药研发过程中进行粗筛实验。其指标参数能够良好地反映动物对药物产生的气道高反应情况，适合于需要动物在*自然状态下呼吸的研究以及长期跟踪实验。

每个体描箱都具备雾化攻击、温湿度补偿接口，另外还具有供水接口和气体采样接口以适用于各种特殊需要的研究。

Whole body plethysmography is an application whereby ventilatory parameters are measured while the subject is conscious and unrestrained. By the use of bias airflow supplies， CO2 levels， temperature and humidity are maintained at normal levels enabling measurements to be made over several hours.

During inspiration there is a slight net pressure rise within theplethysmograph due to increased temperature and humidity of the air as it enters the subject’s lungs (gas conditioning). During normal breathing， this pressure difference is directly proportional to the respiratory pattern of the subject， allowing the researcher to measure respiratory rate and tidal volume， in accordance with ICH S7 Guidelines.

The system is commonly used in airway hyper-reactivity studieswhere， in addition to changes in ventilatory parameters， valuable data can obtained

by quantifying changes in the shape of the respiratory waveform， e.g.， Penh. However， it should be noted that when bronchoconstriction is present，

the respiratory signal is dominated by the effects of gas compression and therefore exact measures of tidal volume can not be determined.

Parameters Measured

· Breathing frequency

· Tidal volume (during normal breathing)

· Minute volume

· Penh (enhanced pause)

· Inspiration time

· Expiration time

· Peak inspiratory flow

· Peak expiratory flow

· Explanation and more parameters

Features

· Non-invasive

· Real time tidal volume measurement using multiple compensation factors (e.g. Epstein & Epstein， Drorbaugh & Fenn)

· Real time environmental monitoring (atmospheric pressure， temperature， humidity)

· Subject is unrestrained and conscious

· No anaesthesia

· Range of species including guinea pigs， rats and mice

· Chronic and long term use

· Measurement during aerosol challenge

·Up to sixteen animals measured simultaneously

· Optional body temperature measurement through telemetry

Uses

· Airway hyper-reactivity models

· Late phase response studies

· Chronic studies

· Drug screening

· Toxicology

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