无创伤肺功能检测 Non-invasive Airway Mechanics

本系统提供长期跟踪研究的另一种选择，即可对同一动物进行多次跟踪检测。实验动物处于清醒但不能自由活动的状态。该系统使用双腔式体积描记器，对动物的头部和胸部气流分别进行测定并计算得出比气道阻力（ｓＲａｗ）和比气道传导率（ｓＧａｗ）。可根据需要加配雾化给药系统。

产品特点：

? 可同时观测多只动物，并适合长期跟踪研究；清洁，完整的设计。使用*少的管线连接一个平台就可同时监测多达四只动物；

? SRaw和SGaw参数与有创方式测定的气道阻力具有高度相关性；

? 动物实验准备较全身体积描记法复杂；

? 一个平台就可应用于小鼠，大鼠和豚鼠-只需搭配不同的动物腔室即可；

? 自动感应物种种类和调整分析设置；

The EMMS non-invasive airway mechanics system uses a classic Pennock style double-chamber plethysmograph to measure nasal and thoracic flow. The animal is placed in a double-chamber plethysmograph (eg. PLY 230 for guinea pig)， and is restrained in the chamber with a rubber neck collar. This neck collar also provides an airtight seal between the thoracic and nasal chambers. Flow in the two chambers is measured across two pneumotachographs in the plethysmograph wall. A bias flow air supply is used to prevent build-up of CO2 in the plethysmograph， and may also be used to pull aerosol through the nasal chamber.

Parameters Measured

· Specific Airway Resistance

· Specific Airway Conductance

· Tidal Volume

· Minute Volume

· Time of Inspiration

· Time of Expiration

· Peak Expiratory Flow

· Peak Inspiratory Flow

· Respiratory Rate

· Explanations and more parameters

Features

· Up to 8 animals monitored simultaneously

· Completely non-invasive

· No anaesthesia required

· Aerosol can be administered via the nasal chamber

Uses

· Chronic studies

· Suitable for long-term measurements

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